Systemic Therapy
Systemic drugs such as methotrexate, cyclosporine and acitretin are used in widespread or resistant psoriasis and eczema, alongside laboratory and safety monitoring.
Clinic and treatment images
Tap to enlargeHow it is applied
The right drug is chosen together, guided by disease type, severity and other conditions.
Baseline laboratory screening checks liver, kidney and blood values before starting.
The dose is titrated gradually while regular blood tests track safety and response.
Response is measured with PASI/EASI/DLQI and stepped to phototherapy or a biologic.
Who it suits
- People with widespread or stubborn psoriasis and eczema where topicals alone fall short.
- Selected patients without phototherapy access or needing rapid systemic control.
- Those able to keep regular laboratory monitoring, with pregnancy plans considered.
Systemic drugs need regular blood monitoring; some cannot be used in pregnancy, and alcohol and drug interactions are considered.
Why Clinovia?
Psoriasis and eczema are not only a surface problem. We assess the skin barrier, inflammation, nutrition and lifestyle, comorbidities and dermatological treatment together. Evidence-based dermatology remains the backbone; nutrition and lifestyle support that plan.
The Gut–Skin Relationship
We review digestive symptoms, dietary pattern and food-sensitivity history. The link between gut microbiome and inflammatory skin disease is still being researched, so it is addressed alongside — never instead of — dermatological treatment.
Cortisone-Free Protocol
First-line calcineurin and PDE-4 inhibitors, ceramide-based barrier repair and phototherapy instead of steroids; systemic and biologic steps when needed.
Systemic Repair
Vitamin D, zinc, omega-3 and iron levels plus thyroid and insulin resistance are screened, and any deficits found are built into the plan.
Measurable Follow-up
PASI/EASI and DLQI scores are tracked alongside laboratory values; steps that do not deliver a response are removed from the plan.
Our standard protocols are cortisone-free. We work with topical calcineurin inhibitors, PDE-4 inhibitors, ceramide-based barrier repair, NB-UVB phototherapy and biologic agents when needed. Cortisone is considered only for very short, unavoidable situations and with the patient's consent.
NB-UVB is safe when cumulative dose is monitored. A typical course is 20–30 sessions at two to three per week; the first response usually appears within 4–6 weeks.
Patients with moderate-to-severe psoriasis or severe atopic dermatitis who did not respond adequately to phototherapy and systemic therapy. Eligibility is confirmed after screening tests.
All treatments
NB-UVB PhototherapyNarrowband UVB at 311 nm calms inflammation in psoriasis and eczema without cortisone. Sessions run two to three times a week, with a typical course of 20–30 and PASI/EASI tracking.
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PUVA & Targeted PhototherapyPUVA and targeted local units treat stubborn sites such as hands, feet and scalp with cortisone-free light. Dose and response are monitored throughout the course.
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Biologic TreatmentsBiologic drugs selectively block targets such as IL-17 and IL-23 in psoriasis and IL-4/13 in eczema. They are considered in moderate-to-severe, resistant disease after screening.
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Let's build the right plan for your skin today
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- Defterdar, Fethi Çelebi Cd. No:15, 34050 Eyüpsultan/İstanbul, Türkiye
- Mon–Sat: 09:00 – 19:00